01 / 07 · Systematic Reviews

Systematic Review Services

PRISMA 2020-Compliant Evidence Synthesis for High-Impact Publication

A systematic review is the highest-impact form of evidence synthesis in medical research. When conducted with methodological rigour and reported to PRISMA 2020 standards, it becomes the foundation of clinical guidelines, funding decisions, and policy change. Our systematic review services cover every stage — from PICO formulation and PROSPERO registration to peer-review response and final acceptance.

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Systematic Reviews

PRISMA 2020-Compliant Evidence Synthesis for High-Impact Publication

42+RCTs in Largest Review

8+Databases Searched

Q1Target Journal Tier

PRISMA 2020PROSPERORayyanCovidenceCochrane RoB 2.0ROBINS-IQUADAS-2GRADEGRADEproRevMan 5StataR

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Response within 24 hours

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What Is It?

Understanding Systematic Reviews

A systematic review uses a pre-specified, reproducible methodology to identify, critically appraise, and synthesise all available evidence on a defined clinical question. Unlike narrative reviews, every decision — from search strategy to inclusion criteria — is documented and justified, making systematic reviews the most trusted form of evidence in clinical medicine.

The PRISMA 2020 statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) provides a 27-item checklist and flow diagram that is now mandatory for submission to The Lancet, JAMA, BMJ, Cochrane Library, and hundreds of specialty journals worldwide.

Why It Matters for Publication

Required by Q1 journals including The Lancet, JAMA, and BMJ

Peer reviewers assess methodology quality before evaluating science

Methodological rigour directly determines acceptance probability

MD. Massab Bashir has supported 20+ Q1 publications

97%

Job Success Score on Upwork

What's Included

Every Deliverable — Documented

No vague promises. Every engagement specifies exactly what you receive, at what standard, by what deadline.

PICO Framework & Protocol Development

Precisely defined Population, Intervention, Comparator, and Outcome with pre-specified eligibility criteria, outcomes, and search strategy.

PROSPERO Registration

Full protocol preparation and PROSPERO submission before any data collection begins — required by most Q1 journals.

Multi-Database Search Strategy

Comprehensive Boolean search strings across PubMed/MEDLINE, EMBASE, Cochrane CENTRAL, Scopus, Web of Science, and grey literature sources including ClinicalTrials.gov and WHO ICTRP.

Dual Independent Screening

Title/abstract and full-text screening using Rayyan or Covidence by two independent reviewers with documented inter-rater agreement.

Standardised Data Extraction

Pre-piloted extraction forms capturing study design, population, intervention, comparator, outcomes, and results — dual independent with reconciliation.

Risk of Bias Assessment

Cochrane RoB 2.0 for RCTs, ROBINS-I for observational studies, QUADAS-2 for diagnostic studies, or Newcastle-Ottawa Scale — assessed at outcome level per PRISMA 2020.

GRADE Evidence Profiling

Certainty of evidence rated High/Moderate/Low/Very Low for each primary outcome using GRADEpro GDT — now required in abstracts of major journals.

PRISMA 2020-Compliant Manuscript

Full IMRaD-structured manuscript with PRISMA flow diagram, completed 27-item checklist, and targeted to your specified journal's author guidelines.

Tools & Methodologies

PRISMA 2020PROSPERORayyanCovidenceCochrane RoB 2.0ROBINS-IQUADAS-2GRADEGRADEproRevMan 5StataR

Who This Is For

PhD students and early-career researchers

Clinicians and medical consultants

University research departments

Hospital-based research teams

Healthcare organisations and NGOs

Researchers targeting Q1 journal publication

The Process

How We Work Together

Transparent, structured engagement from first contact to final delivery — with clear milestones and no surprises.

Free Consultation

We discuss your research question, target journal, timeline, and budget. I provide a tailored service recommendation at no cost.

PICO & Protocol

We define your PICO precisely, draft the full PROSPERO protocol, and register before any searches begin.

Literature Search

Multi-database searches using validated Boolean strings across all relevant databases and grey literature.

Screening & Extraction

Dual-independent title/abstract screening, full-text review, and standardised data extraction with reconciliation.

Appraisal & Synthesis

Risk of bias assessment, quantitative or narrative synthesis, GRADE profiling, and forest plots if meta-analysis is included.

Manuscript & Submission

Full PRISMA 2020-compliant manuscript drafted, PRISMA checklist completed, and submission package prepared.

About Your Consultant

MD. Massab Bashir

Medical Physician · PhD Researcher · Top Rated Plus

🎓Medical Physician with clinical foundation in evidence-based practice

🔬PhD Researcher in Immunology — advanced research methodology

⭐Top Rated Plus on Upwork — 97% Job Success Score

📄20+ Q1 publications supported

Free 30-Minute Consultation

Discuss your project and receive an accurate quote at no cost.

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FAQ

Frequently Asked Questions About Systematic Reviews

What is included in your systematic review services?+

Our systematic review services include the complete lifecycle — PICO formulation, PROSPERO registration, multi-database literature search, dual-independent screening, standardised data extraction, risk of bias assessment (Cochrane RoB 2.0 / ROBINS-I), GRADE evidence profiling, and a full PRISMA 2020-compliant manuscript ready for journal submission. Peer review response support is available as an add-on.

How long does a systematic review take?+

A standard systematic review takes 8–16 weeks depending on the scope, number of databases searched, volume of literature identified, and complexity of the synthesis. Narrow PICO questions with limited literature can be completed in 8 weeks. Comprehensive reviews with network meta-analysis require 12–16 weeks. Rush timelines are available.

Do I need a PROSPERO registration number?+

Yes — PROSPERO registration is now required by most Q1 journals including The Lancet, JAMA, BMJ, and Cochrane. It must be completed before any data collection begins. We handle the full protocol preparation and submission as part of our systematic review service.

Can you conduct a systematic review on any medical topic?+

Yes. Our systematic review services cover all biomedical and clinical disciplines including oncology, immunology, cardiology, infectious disease, neurology, obstetrics, critical care, emergency medicine, and allied health specialties. We also support systematic reviews in pharmacy, nursing, and public health.

What databases do you search for the literature?+

Our standard multi-database search covers PubMed/MEDLINE, EMBASE, Cochrane CENTRAL, Scopus, Web of Science, CINAHL (if relevant), ClinicalTrials.gov, WHO ICTRP, and grey literature sources appropriate to your field. We document all search strings, date ranges, and filters for full PRISMA 2020 compliance.

What risk of bias tool do you use?+

We use the tool matched to your study type: Cochrane RoB 2.0 for randomised controlled trials, ROBINS-I for non-randomised studies of interventions, QUADAS-2 for diagnostic accuracy studies, and Newcastle-Ottawa Scale for cohort and case-control studies. Risk of bias is always assessed at the outcome level as required by PRISMA 2020.

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Let's Discuss Your Systematic Reviews Project

Free 30-minute consultation. No obligation. Tailored recommendation and accurate quote within 24 hours.

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